Dr. Annie Lowrie Alexander was born January 10, 1864 near Cornelius in Mecklenburg County, N.C. Her parents were Dr. John Brevard Alexander (1834-1911) and Ann Wall Lowrie Alexander (1834-1893).
Alexander graduated from Woman's Medical College in Philadelphia in 1884. After a year as an intern at the college, she became an assistant teacher of anatomy at the Woman's Medical College of Baltimore, Maryland. She returned to North Carolina in 1887 as the first woman to practice medicine in the South.
Although medicine was considered an improper field for women, Alexander gained the respect of her community. In 1909 she was elected to her first of several terms as president of the Mecklenburg County Medical Society. She also served on the staffs of St. Peter's Hospital (now Carolinas Medical Center) and Presbyterian Hospital and on the boards of the Charlotte YWCA, the Florence Crittendon Maternity Home, the Associated Charities, and the Cooperative Nursing Association. During World War I, Alexander became a first lieutenant in the army and worked in North Carolina with the U.S. Health Service, serving as acting assisting surgeon at Camp Greene in Charlotte. For 23 years, she served as the physician to the Presbyterian College for Women (now Queens College).
Alexander never married. She died October 15, 1929 in Charlotte from pneumonia, an illness she contracted from a patient. She is buried in Elmwood Cemetery in Charlotte.
[For more information, see William S. Powell, ed., The Dictionary of North Carolina Biography, vol. 1 (1979).]